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Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites.
Gene Name: | ubiquitin specific peptidase 48 |
Synonyms: | USP48, Deubiquitinating enzyme 48, Ubiquitin specific protease 48, Ubiquitin thioesterase 48, RAP1GA1, Ubiquitin specific protease 31, Ubiquitin thiolesterase 48 |
Target Sequences: | NM_032236 NP_115612.4 Q86UV5 |
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