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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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USP34
ubiquitin specific peptidase 34
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
| Gene Name: | ubiquitin specific peptidase 34 |
| Synonyms: | USP34, Deubiquitinating enzyme 34, KIAA0729, Ubiquitin specific protease 34, Ubiquitin thioesterase 34, Ubiquitin thiolesterase 34, KIAA0570 |
| Target Sequences: | AB011142 BAA25496.2 Q70CQ2 |
![USP34 Antibody - Immunoperoxidase of monoclonal antibody to USP34 on formalin-fixed paraffin-embedded human seminoma. [antibody concentration 3 ug/ml].](https://lsbio-7d62.kxcdn.com/image2/usp34-antibody-clone-2e2-ls-c133602/52258_5189026.jpg)
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