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USP20 / VDU2

ubiquitin specific peptidase 20

Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Gene Name: ubiquitin specific peptidase 20
Family/Subfamily: Protease , Cysteine C19
Synonyms: USP20, Deubiquitinating enzyme 20, Ubiquitin specific protease 20, Ubiquitin thioesterase 20, HVDU2, KIAA1003, LSFR3A, Ubiquitin thiolesterase 20, VDU2
Target Sequences: NM_006676 NP_006667.3 Q9Y2K6

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Products
Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
USP20 / VDU2 (7)
No (7)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (5)
Human (5)
293T Cells (2)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (1)
USP20 / VDU2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
USP20 / VDU2 Protein - Purified recombinant protein USP20 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
101.7 kDa
20 µg/$1,107
USP20 / VDU2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
101.7 kDa
20 µg/$215
USP20 / VDU2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
101.7 kDa
20 µg/$150
USP20 / VDU2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
101.7 kDa
100 µg/$494
USP20 / VDU2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
101.7 kDa
100 µg/$710
USP20 / VDU2 Protein - 12.5% SDS-PAGE of human USP20 stained with Coomassie Blue
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Wheat Germ Extract
GST
128.3 kDa
10 µg/$479; 25 µg/$670
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).