USP10

ubiquitin specific peptidase 10

Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.

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Products

Antibodies (37)

Type

Primary (37)

Target

USP10 (37)

Reactivity

Human (36)

Mouse (14)

Rat (9)

Bat (3)

Bovine (3)

Chicken (3)

Dog (5)

Gibbon (6)

Guinea pig (3)

Horse (3)

Monkey (8)

Pig (3)

Rabbit (3)

Xenopus (3)

Zebrafish (3)

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Application

IHC (14)

IHC-P (6)

WB (31)

Flo (6)

ELISA (10)

ICC (1)

IF (10)

IP (4)

Peptide-ELISA (1)

Host

rabbit (31)

mouse (6)

Product Group

IHCPlus (2)

Isotype

IgG (21)

IgG1 (2)

IgG2a (2)

IgG2b (2)

Clonality

monoclonal mc (6)

polyclonal pc (31)

Clone

OTI1A10 (2)

OTI1H9 (2)

OTI2E1 (2)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (4)

Carrier-free (3)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (1)

Unconjugated (23)

Epitope

aa500-529 (7)

aa301-350 (4)

aa487-536 (4)

aa50-100 (2)

aa300-3500 (1)

Publications

No (37)

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IHC-plus™ USP10 Antibody LS-B5278

(4.0) Rating

Antibody:

USP10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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USP10 Antibody (aa487-536) LS-C145246

Antibody:

USP10 Rabbit anti-Rat Polyclonal (aa487-536) Antibody

Reactivity:

Rat

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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USP10 Antibody (clone OTI2E1) LS-C173493

Antibody:

USP10 Mouse anti-Human Monoclonal (OTI2E1) Antibody

Reactivity:

Mouse, Dog, Rat, Human, Monkey

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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USP10 Antibody (clone OTI2E1, Carrier-free) LS-C786652

Antibody:

USP10 Mouse anti-Human Monoclonal (Carrier-free) (OTI2E1) Antibody

Reactivity:

Mouse, Dog, Rat, Human, Monkey

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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IHC-plus™ USP10 Antibody (aa50-100) LS-B14418

(4.0) Rating

Antibody:

USP10 Rabbit anti-Human Polyclonal (aa50-100) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$485

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USP10 Antibody (clone OTI1H9) LS-C173574

Antibody:

USP10 Mouse anti-Human Monoclonal (OTI1H9) Antibody

Reactivity:

Human, Monkey

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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USP10 Antibody (clone OTI1H9, Carrier-free) LS-C799403

Antibody:

USP10 Mouse anti-Human Monoclonal (Carrier-free) (OTI1H9) Antibody

Reactivity:

Human, Monkey

Applications:

Flo, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

USP10 Antibody (clone OTI1A10) LS-C173656

Antibody:

USP10 Mouse anti-Human Monoclonal (OTI1A10) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

USP10 Antibody (clone OTI1A10, Carrier-free) LS-C799415

Antibody:

USP10 Mouse anti-Human Monoclonal (Carrier-free) (OTI1A10) Antibody

Reactivity:

Human

Applications:

Flo, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

USP10 Antibody LS-C670986

Antibody:

USP10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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USP10 Antibody LS-C754695

Antibody:

USP10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

USP10 Antibody LS-C349200

Antibody:

USP10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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USP10 Antibody LS-C748438

Antibody:

USP10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

USP10 Antibody LS-C771658

Antibody:

USP10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

USP10 Antibody LS-C191378

Antibody:

USP10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IF, IP, WB

Format:

Unconjugated

Price:

100 µl/$688

Select

USP10 Antibody (aa300-3500) LS-C287738

Antibody:

USP10 Rabbit anti-Human Polyclonal (aa300-3500) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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USP10 Antibody LS-C771657

Antibody:

USP10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

USP10 Antibody LS-C779703

Antibody:

USP10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

USP10 Antibody (aa500-529) LS-C326224

Antibody:

USP10 Rabbit anti-Human Polyclonal (aa500-529) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

USP10 Antibody (aa500-529, Biotin) LS-C273153

Antibody:

USP10 Rabbit anti-Human Polyclonal (aa500-529) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

USP10 Antibody (aa500-529, FITC) LS-C273154

Antibody:

USP10 Rabbit anti-Human Polyclonal (aa500-529) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

USP10 Antibody (aa500-529, APC) LS-C273152

Antibody:

USP10 Rabbit anti-Human Polyclonal (aa500-529) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

USP10 Antibody (aa500-529, Azide-free, HRP) LS-C273155

Antibody:

USP10 Rabbit anti-Human Polyclonal (aa500-529) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

USP10 Antibody (aa500-529, PE) LS-C273157

Antibody:

USP10 Rabbit anti-Human Polyclonal (aa500-529) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

USP10 Antibody LS-C806974

Antibody:

USP10 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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