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Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
Gene Name: | ubiquitin specific peptidase 1 |
Family/Subfamily: | Protease , Cysteine C19 |
Synonyms: | USP1, Deubiquitinating enzyme 1, Ubiquitin thioesterase 1, UBP, Ubiquitin thiolesterase 1, Ubiquitin specific protease 1, HUBP, Ubiquitin specific peptidase 1 |
Target Sequences: | NM_003368 NP_003359.3 O94782 |
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