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The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).
Gene Name: | uridine phosphorylase 1 |
Synonyms: | UPP1, UPASE, Uridine phosphorylase, Uridine phosphorylase 1, UPase 1, UPP, UrdPase 1, UDRPASE, UP |
Target Sequences: | NM_003364 NP_003355.1 Q16831 |
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