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Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.
Gene Name: | unc-93 homolog B1 (C. elegans) |
Synonyms: | UNC93B1, IIAE1, Unc-93 homolog B1 (C. elegans), UNC93, UNC93B, Protein unc-93 homolog B1, Unc93 homolog B, HUNC93B1, Unc-93 related protein, Unc-93B1, Unc93 (C. elegans) homolog B1, Unc93 homolog B1 |
Target Sequences: | NM_030930 NP_112192.2 Q9H1C4 |
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