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UNC5H2 / UNC5B

unc-5 homolog B (C. elegans)

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.

Gene Name: unc-5 homolog B (C. elegans)
Synonyms: UNC5B, p53RDL1, Unc-5 homolog B (C. elegans), Netrin receptor UNC5B, UNC5H2, Transmembrane receptor Unc5H2, Unc5 (C.elegans homolog) b, Protein unc-5 homolog 2, Protein unc-5 homolog B, Unc-5 homolog 2
Target Sequences: Q8IZJ1 Q8IZJ1

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
UNC5H2 / UNC5B (6)
No (6)
Fc (1)
GST, N-terminus (1)
Human IgG1 Fc (1)
Myc-DDK (Flag) (3)
Human (4)
Rat (1)
293T Cells (1)
HEK 293 Cells (3)
Human Cells (1)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (2)
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Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
65.7 kDa
100 µg/$721
UNC5H2 / UNC5B Protein - Purified recombinant protein UNC5B was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
103.5 kDa
20 µg/$1,107
UNC5H2 / UNC5B Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
UNC5H2 / UNC5B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
103.5 kDa
100 µg/$710
UNC5H2 / UNC5B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
103.5 kDa
20 µg/$215
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HEK 293 Cells
Human IgG1 Fc
Less than 0.1 EU/µg protein (determined by LAL method).
~80kDa (SDS-PAGE).
50 µg/$379
Viewing 1-6 of 6 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).