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UNC5H2 / UNC5B
unc-5 homolog B (C. elegans)
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
| Gene Name: | unc-5 homolog B (C. elegans) |
| Synonyms: | UNC5B, p53RDL1, Unc-5 homolog B (C. elegans), Netrin receptor UNC5B, UNC5H2, Transmembrane receptor Unc5H2, Unc5 (C.elegans homolog) b, Protein unc-5 homolog 2, Protein unc-5 homolog B, Unc-5 homolog 2 |
| Target Sequences: | Q8IZJ1 Q8IZJ1 |
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