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UMOD / Uromodulin

uromodulin

UMOD / Uromodulin is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.

Gene Name: uromodulin
Synonyms: UMOD, ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP, Uromucoid, Tamm-Horsfall glycoprotein, HNFJ1, Uromodulin
Target Sequences: NM_003361 NP_003352.2 P07911

Publications (6)

1
Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control study. Jayachandran M, Lugo G, Heiling H, Miller VM, Rule AD, Lieske JC. Biology of sex differences. 2015 6:2. (Flo; Human) [Full Text Article] [PubMed:25729563] [PMC:PMC4345020] Related Antibodies: LS-B3105.
2
Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys. Turco AE, Lam W, Rule AD, Denic A, Lieske JC, Miller VM, Larson JJ, Kremers WK, Jayachandran M. Journal of Extracellular Vesicles. 2016 5:29642. (Flo; Human) [PubMed:26837814] [PMC:PMC4737715] Related Antibodies: LS-B3105.
3
Novel fixed z-direction (FiZD) kidney primordia and an organoid culture system for time-lapse confocal imaging. Saarela U, Akram SU, Desgrange A, Rak-Raszewska A, Shan J, Cereghini S, Ronkainen VP, Heikkilä J, Skovorodkin I, Vainio SJ. Development (Cambridge, England). 2017 144:1113-1117. (IHC; Mouse) [Full Text Article] [PubMed:28219945] [PMC:PMC5358112]
4
Urinary extracellular vesicle-associated MCP-1 and NGAL derived from specific nephron segments differ between calcium oxalate stone formers and controls. Robin S Chirackal, Muthuvel Jayachandran, Xiangling Wang, Samuel Edeh, Zejfa Haskic, Majuran Perinpam, Timothy M Halling, Ramila Mehta, Marcelino E Rivera, John C Lieske. American journal of physiology. Renal physiology. 2019 December;317:F1475-F1482. [Full Text Article] [PubMed:31461349] [PMC:PMC6962507] Related Antibodies: LS-B3105.
5
Mouse Embryonic Stem Cell-Derived Ureteric Bud Progenitors Induce Nephrogenesis. Zenglai Tan, Aleksandra Rak-Raszewska, Ilya Skovorodkin, Seppo J Vainio. Cells. 2020 Jan;9:329. [Full Text Article] [PubMed:32023845] [PMC:PMC7072223]
6
Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene. Azuma Nanamatsu, Radmila Micanovic, Shehnaz Khan, Tarek M El-Achkar, Kaice A LaFavers. Kidney360. 2023 September;4:e1302-e1307. [Full Text Article] [PubMed:37340540] [PMC:PMC10475773]
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ELISA Kits (21)
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Sandwich (16)
Sandwich CLIA (3)
UMOD / Uromodulin (21)
Human (9)
Mouse (6)
Rat (4)
Dog (1)
12 x 8-Well Microstrips (3)
96-Well Microplate (4)
96-Well Strip Plate (13)
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Cell Culture Supernatants (2)
Heparin Plasma (1)
Plasma (18)
Serum (19)
Tissue Homogenates (5)
Urine (5)
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$783
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$748
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Microplate
Human
40.96 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$760
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$792
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$730
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
UMOD / Uromodulin ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
UMOD / Uromodulin ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
UMOD / Uromodulin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
0.625 - 40 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
UMOD / Uromodulin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
0.313 - 20 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
UMOD / Uromodulin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
0.625 - 40 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
UMOD / Uromodulin ELISA Kit
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Sandwich
Human
156 - 10000 pg/ml
Cell Culture Supernatants, Heparin Plasma, Serum
1 Plate/$699
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$897
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
2.34 - 150 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$968
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Microplate
Rat
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Microplate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).