ULK1

unc-51 like autophagy activating kinase 1

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

ULK1 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human ULK1 Protein (Recombinant GST) (Full Length) - LS-G31140

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

142.45 kDa

Price:

2 µg/$439

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Human ULK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88191

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.4 kDa

Price:

20 µg/$215

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Human ULK1 Protein (Recombinant GST, N-terminus) (aa602-715) - LS-G60710

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ULK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70868

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.4 kDa

Price:

20 µg/$1,107

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ULK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117243

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.4 kDa

Price:

100 µg/$710

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