UGT1A / UGT1A1

UDP glucuronosyltransferase 1 family, polypeptide A1

UGT1A / UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

UGT1A / UGT1A1 (7)

Publications

No (7)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (1)

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Human UGT1A / UGT1A1 Protein (Recombinant 6His, N-terminus) (aa26-533) - LS-G23182

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

59.1 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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Human UGT1A / UGT1A1 Protein (Recombinant His) - LS-G3226

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human UGT1A / UGT1A1 Protein (Recombinant GST, N-terminus) (aa54-159) - LS-G62606

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human UGT1A / UGT1A1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70781

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.1 kDa

Price:

20 µg/$1,107

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Human UGT1A / UGT1A1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87976

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.59 kDa

Price:

20 µg/$215

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UGT1A / UGT1A1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123168

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.59 kDa

Price:

100 µg/$710

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Human UGT1A / UGT1A1 Protein (Recombinant His, N-Terminal) (His26-Gly276) - LS-G133023

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32.0kDa

Price:

10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,838

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