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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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UGT1A / UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A / UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
| Gene Name: | UDP glucuronosyltransferase 1 family, polypeptide A1 |
| Synonyms: | UGT1A1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1A, BILIQTL1, UGT1, UGT1*1, UGT1-01, UGT-1A, UGT1.1 |
| Target Sequences: | NM_000463 NP_000454.1 P22309 |
Publications (1)
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