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Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.
Gene Name: | ubiquitin carboxyl-terminal hydrolase L5 |
Family/Subfamily: | Protease , Cysteine C12 |
Synonyms: | UCHL5, CGI-70, INO80 complex subunit R, INO80R, Ubiquitin thioesterase L5, UCH37, UCH-L5 |
Target Sequences: | NM_015984 NP_057068.1 Q9Y5K5 |
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