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Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation.
Gene Name: | ubiquitin-conjugating enzyme E2R 2 |
Synonyms: | UBE2R2, CDC34B, E2-CDC34B, UBC3B, Ubiquitin carrier protein R2, Ubiquitin-protein ligase R2 |
Target Sequences: | NM_017811 NP_060281.2 Q712K3 |
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