UBE2O

ubiquitin-conjugating enzyme E2O

E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853).

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

UBE2O (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human UBE2O Protein (Recombinant GST) (Full Length) - LS-G34896

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

108.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human UBE2O Protein (Recombinant GST, N-terminus) (aa361-470) - LS-G63056

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human UBE2O Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87402

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

141.1 kDa

Price:

20 µg/$215

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Human UBE2O Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70546

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

141.1 kDa

Price:

20 µg/$1,107

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UBE2O Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110501

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

141.1 kDa

Price:

100 µg/$710

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