UBE2N / UBC13

ubiquitin-conjugating enzyme E2N

The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

UBE2N / UBC13 (5)

Publications

No (5)

Tag

6His, N-terminus (1)

GST (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human UBE2N / UBC13 Protein (Recombinant 6His, N-terminus) - LS-G1218

Source:

E. coli

Tag:

6His, N-terminus

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human UBE2N / UBC13 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67267

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17 kDa

Price:

20 µg/$1,107

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Human UBE2N / UBC13 Protein (Recombinant GST) (Full Length) - LS-G30823

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

42.46 kDa

Price:

10 µg/$479; 25 µg/$670

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Human UBE2N / UBC13 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79447

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17 kDa

Price:

20 µg/$150

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UBE2N / UBC13 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117397

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17 kDa

Price:

100 µg/$494

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