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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene Name: | ubiquitin-conjugating enzyme E2E 1 |
Synonyms: | UBE2E1, UBCH6, Ubiquitin-protein ligase E1, Ubiquitin carrier protein E1 |
Target Sequences: | BC009139 NP_003332.1 P51965 |
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