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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | ubiquitin-conjugating enzyme E2D 1 |
Synonyms: | UBE2D1, SFT, Ubiquitin-protein ligase D1, UBC4/5 homolog, UBCH5, UBCH5A, UBC4/5, UBC5A, Ubiquitin carrier protein D1, E2(17)KB1, Stimulator of Fe transport |
Target Sequences: | NM_003338 NP_003329.1 P51668 |
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