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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
Gene Name: | ubiquitin-like modifier activating enzyme 7 |
Synonyms: | UBA7, D8, UBA1B, UBE1L, Ubiquitin-activating enzyme 7, UBE2, Ubiquitin-activating enzyme-2 |
Target Sequences: | NM_003335 NP_003326.2 P41226 |
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