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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
Gene Name: | ubiquitin-conjugating enzyme E2H |
Synonyms: | UBE2H, GID3, UBC8, Ubiquitin carrier protein H, UBCH, Ubiquitin-protein ligase H, E2-20K, UBCH2 |
Target Sequences: | NM_003344 NP_003335.1 P62256 |
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