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Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1.
Gene Name: | Uveal Autoantigen With Coiled-coil Domains And Ankyrin Repeats |
Synonyms: | UACA, NUCLING, KIAA1561 |
Target Sequences: | AF322916 AAG49577.1 Q9BZF9 |
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