TYRO3

TYRO3 protein tyrosine kinase

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

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Products

Proteins (12)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

TYRO3 (12)

Publications

No (12)

Tag

DDK (Flag)-His, C-terminus (1)

DDK,C-terminus (1)

Fc, C-terminus (2)

GST, N-terminus (1)

His, C-Terminal (1)

His,C-terminus (1)

mFc, C-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (7)

Mouse (4)

Source

293T Cells (1)

HEK 293 Cells (3)

Human (1)

Human Cells (2)

Mammalian Cells (3)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (6)

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Human TYRO3 Protein (Recombinant His, C-Terminal) (Ala41-Ser428) - LS-G55735

Source:

Human

Tag:

His, C-Terminal

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.4kD

Price:

10 µg/$262; 50 µg/$321; 500 µg/$802; 1 mg/$1,113

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Human TYRO3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78583

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

96.7 kDa

Price:

20 µg/$150

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Mouse TYRO3 Protein (Recombinant Fc, C-terminus) (Ala31-Ser418) - LS-G138594

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

68.9 kDa

Price:

10 µg/$233; 50 µg/$277

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Human TYRO3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66844

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

96.7 kDa

Price:

20 µg/$1,107

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Human TYRO3 Protein (Recombinant GST, N-terminus) (aa50-150) - LS-G60457

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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TYRO3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100783

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

96.7 kDa

Price:

100 µg/$494

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Human TYRO3 Protein (Recombinant DDK,C-terminus) - LS-G142408

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

41.6 kDa

Price:

20 µg/$677

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Human TYRO3 Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142233

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

44 kDa

Price:

20 µg/$1,107

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Human TYRO3 Protein (Recombinant His,C-terminus) (Ala41-Ser428) - LS-G138748

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

42.4 kDa

Price:

10 µg/$262; 50 µg/$317

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Mouse TYRO3 Protein (Recombinant mFc, C-terminus) (Ala31-Ser418) - LS-G138645

Source:

Mammalian Cells

Tag:

mFc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

68.2 kDa

Price:

10 µg/$248; 50 µg/$288

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Mouse TYRO3 Protein (Recombinant mFc, C-terminus) (Ala31-Ser418) - LS-G40007

Source:

Human Cells

Tag:

mFc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

68.2kD

Price:

10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203

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Mouse TYRO3 Protein (Recombinant Fc, C-terminus) (Ala31-Ser418) - LS-G40122

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

68.9kD

Price:

10 µg/$233; 50 µg/$277; 500 µg/$725; 1 mg/$1,113

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