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TYK2 is a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Gene Name: | tyrosine kinase 2 |
Family/Subfamily: | Protein Kinase , TYK2/JAK |
Synonyms: | TYK2, Tyrosine kinase 2, JTK1 |
Target Sequences: | NM_003331 NP_003322.3 P29597 |
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