TXK / RLK

TXK tyrosine kinase

Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

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Products

Antibodies (26)

Type

Primary (26)

Target

TXK / RLK (26)

Reactivity

Human (18)

Mouse (10)

Rat (2)

Application

IHC (11)

IHC-P (4)

WB (21)

ELISA (13)

IF (4)

Peptide-ELISA (2)

Host

rabbit (24)

mouse (1)

goat (1)

Product Group

IHCPlus (2)

Isotype

IgG (14)

IgG2a,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (25)

Clone

2D8 (1)

Format

APC (1)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (3)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (2)

Unconjugated (11)

Epitope

aa286-509 (8)

aa22-52 (7)

Internal (1)

aa515-527 (1)

Publications

No (26)

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TXK / RLK Antibody LS-C412230

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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TXK / RLK Antibody (clone 2D8) LS-C198387

Antibody:

TXK / RLK Mouse anti-Human Monoclonal (2D8) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$335

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TXK / RLK Antibody (aa286-509) LS-C296896

Antibody:

TXK / RLK Rabbit anti-Mouse Polyclonal (aa286-509) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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TXK / RLK Antibody (aa286-509, HRP) LS-C713788

Antibody:

TXK / RLK Rabbit anti-Mouse Polyclonal (aa286-509) (HRP) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639

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TXK / RLK Antibody (aa286-509, Biotin) LS-C688876

Antibody:

TXK / RLK Rabbit anti-Mouse Polyclonal (aa286-509) (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387

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TXK / RLK Antibody (aa286-509, FITC) LS-C695909

Antibody:

TXK / RLK Rabbit anti-Mouse Polyclonal (aa286-509) (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765

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TXK / RLK Antibody (aa286-509, Cy3) LS-C704774

Antibody:

TXK / RLK Rabbit anti-Mouse Polyclonal (aa286-509) (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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TXK / RLK Antibody (aa286-509, PE) LS-C727859

Antibody:

TXK / RLK Rabbit anti-Mouse Polyclonal (aa286-509) (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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TXK / RLK Antibody (aa286-509, APC) LS-C718968

Antibody:

TXK / RLK Rabbit anti-Mouse Polyclonal (aa286-509) (APC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

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TXK / RLK Antibody (aa286-509, APC, Cy7) LS-C736769

Antibody:

TXK / RLK Rabbit anti-Mouse Polyclonal (aa286-509) (APC, Cy7) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781

• Unconjugated
• HRP
• Biotin
• FITC
• Cy3
• PE
• APC
• More...
  • APC, Cy7

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • Cy3
  • PE
  • APC
  • APC, Cy7

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TXK / RLK Antibody LS-C802405

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$282; 200 µl/$350

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TXK / RLK Antibody LS-C679935

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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TXK / RLK Antibody (Biotin) LS-C679937

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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TXK / RLK Antibody (FITC) LS-C679938

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• Biotin
• FITC

• Unconjugated
• Biotin
• FITC

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IHC-plus™ TXK / RLK Antibody (aa515-527) LS-B10269

(4.0) Rating

Antibody:

TXK / RLK Goat anti-Human Polyclonal (aa515-527) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$375

Select

IHC-plus™ TXK / RLK Antibody (Internal) LS-B15597

(4.0) Rating

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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TXK / RLK Antibody LS-C661345

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

100 µg/$351

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TXK / RLK Antibody (aa22-52) LS-C330687

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal (aa22-52) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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TXK / RLK Antibody (aa22-52, Biotin) LS-C283563

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal (aa22-52) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

TXK / RLK Antibody (aa22-52, FITC) LS-C283562

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal (aa22-52) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

TXK / RLK Antibody (aa22-52, PE) LS-C283565

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal (aa22-52) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

TXK / RLK Antibody (aa22-52, APC) LS-C283560

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal (aa22-52) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

TXK / RLK Antibody (aa22-52, Azide-free, HRP) LS-C283564

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal (aa22-52) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• APC
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • APC
  • HRP, Azide-free

Select

TXK / RLK Antibody (aa22-52) LS-C99395

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal (aa22-52) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

TXK / RLK Antibody LS-C749776

Antibody:

TXK / RLK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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