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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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TUT1
terminal uridylyl transferase 1, U6 snRNA-specific
Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.
| Gene Name: | terminal uridylyl transferase 1, U6 snRNA-specific |
| Synonyms: | TUT1, RNA binding motif protein 21, RNA-binding protein 21, STARPAP, U6 TUTase, U6-TUTase, RBM21, RNA uridylyltransferase, PAPD2, RNA-binding motif protein 21, Star-PAP, TUTase |
| Target Sequences: | NM_022830 NP_073741.2 Q9H6E5 |
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