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TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).
Gene Name: | tubulin tyrosine ligase |
Synonyms: | TTL, Tubulin tyrosine ligase, Tubulin--tyrosine ligase, Tubulin-tyrosine ligase |
Target Sequences: | AA702175 NP_714923.1 Q8NG68 |
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