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TTF1 / Txn Termination Factor is a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression.
Gene Name: | transcription termination factor, RNA polymerase I |
Synonyms: | TTF1, TTF-I, TTF-1 |
Target Sequences: | NM_007344 NP_031370.2 Q15361 |
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