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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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TSLP
thymic stromal lymphopoietin
TSLP is a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.
Keratin-dependent thymic stromal lymphopoietin expression suggests a link between skin blistering and atopic disease. Kumar V, Behr M, Kiritsi D, Scheffschick A, Grahnert A, Homberg M, Schwieger-Briel A, Jakob T, Bruckner-Tuderman L, Magin TM. The Journal of allergy and clinical immunology. 2016 138:1461-1464. (WB; Human)[Full Text Article]
[PubMed:27527262]
Related Antibodies: LS-B3208.
2
Increased expression of epidermal thymic stromal lymphopoietin in inflammatory peeling skin syndrome. Taizo Wada, Tomoko Toma, Yasuhito Hamaguchi, Akihiro Yachie. The Journal of dermatology. 2014 May;41:448-9. [Full Text Article]
[PubMed:24628284]
Related Antibodies: LS-B3208.
3
Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor beta . Christmann RB, Mathes A, Affandi AJ, Padilla C, Nazari B, Bujor AM, Stifano G, Lafyatis R. Arthritis and rheumatism. 2013 May;65:1335-46. (IHC; Mouse)[Full Text Article]
[PubMed:23335246]
Related Antibodies: LS-B3208.
4
Bronchial Allergen Challenge of Patients with Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa. Wang W, Li Y, Lv Z, Chen Y, Li Y, Huang K, Corrigan CJ, Ying S. Journal of immunology (Baltimore, Md. : 1950). 2018 October;201:2221-2231. [Full Text Article]
[PubMed:30185520]
Related Antibodies: LS-B614.
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).