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TSHB / TSH-Beta

thyroid stimulating hormone, beta

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants.

Gene Name: thyroid stimulating hormone, beta
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: TSHB, Thyrotropin alfa, Thyrotropin beta subunit, TSH Beta, TSH-B, Thyrotropin beta chain, Thyrotropin subunit beta, TSH-BETA, CHNG4
Target Sequences: NM_000549 NP_000540.2 P01222

Publications (2)

1
MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression. Zhang Z, Florez S, Gutierrez-Hartmann A, Martin JF, Amendt BA. The Journal of biological chemistry. 2010 285:34718-28. (IHC-P; Mouse) [PubMed:20807761] [PMC:PMC2966087]
2
Thyroid hormone receptor ß sumoylation is required for thyrotropin regulation and thyroid hormone production. Sujie Ke , Yan-Yun Liu, Rajendiran Karthikraj, Kurunthachalam Kannan, Jingjing Jiang , Kiyomi Abe , Anna Milanesi, Gregory A Brent. JCI insight. 2021 Aug;6:e149425. [Full Text Article] [PubMed:34237030] [PMC:PMC8410017] Related Antibodies: LS-C334949.

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TSHB / TSH-Beta (8)
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Tissue Homogenates (2)
TSHB / TSH-Beta ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
0.156 - 10 µIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TSHB / TSH-Beta ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 mIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$441
TSHB / TSH-Beta ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
0.156 - 10 µIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TSHB / TSH-Beta ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$441
TSHB / TSH-Beta ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
1.56 - 100 mIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$441
TSHB / TSH-Beta ELISA Kit
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Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$441
TSHB / TSH-Beta ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$441
TSHB / TSH-Beta ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$441
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).