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Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).
Gene Name: | N-acetyltransferase 8 (GCN5-related, putative) |
Synonyms: | NAT8, ATase2, Camello-like protein 1, CML1, Hcml1, Probable N-acetyltransferase 8, TSC501, TSC510, N-acetyltransferase 8 |
Target Sequences: | NM_003960 NP_003951.3 Q9UHE5 |
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