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Calcium selective cation channel probably involved in Ca2+ uptake in various tissues, including Ca2+ reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca2+-dependent and a slower Ca2+-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg2+ in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
Gene Name: | transient receptor potential cation channel, subfamily V, member 6 |
Family/Subfamily: | Ion Channel , Calcium channel - TRP |
Synonyms: | TRPV6, ABP/ZF, CAT1, CaT-L, CATL, Calcium transport protein 1, Epithelial calcium channel 2, ECAC2, HSA277909, ZFAB, Calcium channel CaT1, Calcium transporter 1, CaT-like, LP6728 |
Target Sequences: | NM_018646 NP_061116.4 Q9H1D0 |
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