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TRPV4

transient receptor potential cation channel, subfamily V, member 4

Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca2+ in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.

Gene Name:	transient receptor potential cation channel, subfamily V, member 4
Family/Subfamily:	Ion Channel , Calcium channel - TRP
Synonyms:	TRPV4, CMT2C, HMSN2C, OTRPC4, SSQTL1, VR-OAC, VRL-2, Osm-9-like TRP channel 4, SPSMA, TRP12, VRL2, VROAC, SMAL
Target Sequences:	NM_021625 NP_067638.3 Q9HBA0

Publications (15)

The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. Ryskamp DA, Witkovsky P, Barabas P, Huang W, Koehler C, Akimov NP, Lee SH, Chauhan S, Xing W, Rentera RC, Liedtke W, Krizaj D. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:7089-101. (WB, IHC-Fr; Mouse, Human) [Full Text Article] [PubMed:21562271] [PMC:PMC3109951] Related Antibodies: LS-C94498.

Neurite outgrowth and synaptophysin expression of postnatal CNS neurons on GaP nanowire arrays in long-term retinal cell culture. Piret G, Perez MT, Prinz CN. Biomaterials. 2013 34:875-87. (ICC, IHC-Fr; Mouse) [PubMed:23131535] Related Antibodies: LS-C94498.

Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference. Arredondo Zamarripa D, Noguez Imm R, Bautista Cortés AM, Vázquez Ruíz O, Bernardini M, Fiorio Pla A, Gkika D, Prevarskaya N, López-Casillas F, Liedtke W, Clapp C, Thébault S. Scientific reports. 2017 7:13094. (IHC; Rat) [Full Text Article] [PubMed:29026201] [PMC:PMC5638810] Related Antibodies: LS-C94498.

Polarity of varicosity initiation in central neuron mechanosensation. Gu Y, Jukkola P, Wang Q, Esparza T, Zhao Y, Brody D, Gu C,. The Journal of cell biology. 2017 216:2179-2199. (IHC; Mouse) [Full Text Article] [PubMed:28606925] Related Antibodies: LS-C94498.

TRPV4 Does Not Regulate the Distal Retinal Light Response. Yarishkin O, Phuong TTT, Lakk M, Križaj D. Advances in experimental medicine and biology. 2018 1074:553-560. [Full Text Article] [PubMed:29721987] [PMC:PMC6414060] Related Antibodies: LS-C94498.

The expression and function of TRPV4 channels in primate retinal ganglion cells and bipolar cells. Gao F, Yang Z, Jacoby RA, Wu SM, Pang JJ. Cell death & disease. 2019 May;10:364. [Full Text Article] [PubMed:31064977] [PMC:PMC6504919] Related Antibodies: LS-A8583, LS-C94498.

Immunocytochemical Profiling of Cultured Mouse Primary Retinal Cells. Marina C Zalis, Sebastian Johansson, Ulrica Englund-Johansson. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2017 Apr;65:223-239. [Full Text Article] [PubMed:28151698] [PMC:PMC5407564] Related Antibodies: LS-C94498.

Mechanisms underlying selective coupling of endothelial Ca 2+<sup> signals with eNOS vs. IK/SK channels in systemic and pulmonary arteries. Matteo Ottolini , Zdravka Daneva, Yen-Lin Chen, Eric L Cope, Ramesh B Kasetti, Gulab S Zode, Swapnil K Sonkusare. The Journal of physiology. 2020 Sep;;598:3577-3596. [Full Text Article] [PubMed:32463112] [PMC:PMC7484264] Related Antibodies: LS-C94498.

Generators of Pressure-Evoked Currents in Vertebrate Outer Retinal Neurons. Ji-Jie Pang, Fan Gao, Samuel M Wu. Cells. 2021 May;10:1288. [Full Text Article] [PubMed:34067375] [PMC:PMC8224636] Related Antibodies: LS-C94498.

Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice. Zdravka Daneva, Matteo Ottolini , Yen Lin Chen, Eliska Klimentova, Maniselvan Kuppusamy, Soham A Shah, Richard D Minshall, Cheikh I Seye, Victor E Laubach, Brant E Isakson, Swapnil K Sonkusare. eLife. 2021 Sep;10:e67777. [Full Text Article] [PubMed:34490843] [PMC:PMC8448527] Related Antibodies: LS-C94498.

TRPV4 channels mediate the mechanoresponse in retinal microglia. Sarah N Redmon, Oleg Yarishkin, Monika Lakk, Andrew Jo, Edin Mustafic, Petr Tvrdik, David Križaj. Glia. 2021 June;69:1563-1582. [Full Text Article] [PubMed:33624376] [PMC:PMC8989051] Related Antibodies: LS-C110035.

Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1. Trine L Toft-Bertelsen, Dagne Barbuskaite, Eva Kjer Heerfordt, Sara Diana Lolansen, Søren Norge Andreassen, Nina Rostgaard, Markus Harboe Olsen, Nicolas H Norager, Tenna Capion, Martin Fredensborg Rath, Marianne Juhler, Nanna MacAulay. Fluids and barriers of the CNS. 2022 September;19:69. [Full Text Article] [PubMed:36068581] [PMC:PMC9450297] Related Antibodies: LS-C94498.

Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling. Bubolz AH, Mendoza SA, Zheng X, Zinkevich NS, Li R, Gutterman DD, Zhang DX. American journal of physiology. Heart and circulatory physiology. 2012 Feb;302:H634-42. [Full Text Article] [PubMed:22140047] [PMC:PMC3353785] Related Antibodies: LS-A8583.

Pregnancy-induced remodelling and enhanced endothelium-derived hyperpolarization-type vasodilator activity in rat uterine radial artery: transient receptor potential vanilloid type 4 channels, caveolae and myoendothelial gap junctions. Senadheera S, Bertrand PP, Grayson TH, Leader L, Murphy TV, Sandow SL. Journal of anatomy. 2013 Dec;223:677-86. [Full Text Article] [PubMed:24128141] Related Antibodies: LS-A8583.

Localization of TRP Channels in Healthy Oral Mucosa from Human Donors. Yalda Moayedi, Stephanie Michlig, Mark Park, Alia Koch, and Ellen A. Lumpkin. eNeuro. 2022 Dec;9: (IHC; Human) [Full Text Article] [PubMed:36635242] Related Antibodies: LS-A8583.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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