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TRPM2
transient receptor potential cation channel, subfamily M, member 2
Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity.
| Gene Name: | transient receptor potential cation channel, subfamily M, member 2 |
| Family/Subfamily: | Ion Channel , Calcium channel - TRP |
| Synonyms: | TRPM2, EREG1, LTrpC-2, LTRPC2, NUDT9L1, KNP3, NUDT9H, Trrp7 |
| Target Sequences: | NM_003307 NP_003298.1 O94759 |
Publications (5)
1
Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. Bai JZ, Lipski J. Neurotoxicology. 2010 31:204-14.
[PubMed:20064552]
2
Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat. Chung KK, Freestone PS, Lipski J. Journal of neurophysiology. 2011 106:2865-75. (ICC, IHC-Fr; Rat)
[PubMed:21900507]
3
TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation. Melzer N, Hicking G, Gbel K, Wiendl H. PloS one. 2012 7:e47617. (ICC; Mouse)
[PubMed:23077651]
[PMC:PMC3470594]
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(30)
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TRPM2
(32)
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(20)
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(18)
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(14)
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(24)
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(9)
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(4)
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(29)
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(3)
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(18)
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(30)
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(4)
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(2)
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(2)
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(2)
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(2)
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(16)
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(5)
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(5)
aa431-480
(4)
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(2)
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(1)
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(1)
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(1)
aa60-119
(1)
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(1)
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(30)
Yes
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(2)
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(1)
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293T Cells
(1)
HEK 293 Cells
(1)
TRPM2 Goat anti-Human Polyclonal (aa1139-1150) Antibody
Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
TRPM2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat
ICC, IF, IHC, WB
Unconjugated
0.1 ml/$386
TRPM2 Rabbit anti-Rat Polyclonal (C-Terminus) (Biotin) Antibody
Mouse, Rat
ICC, IF, IHC, WB
Biotin Conjugated
0.1 ml/$416
TRPM2 Rabbit anti-Rat Polyclonal (C-Terminus) (DY550) Antibody
Mouse, Rat
ICC, IF, IHC, WB
DY550 Conjugated
0.1 ml/$416
TRPM2 Rabbit anti-Rat Polyclonal (C-Terminus) (DY650) Antibody
Mouse, Rat
ICC, IF, IHC, WB
DY650 Conjugated
0.1 ml/$416
TRPM2 Rabbit anti-Rat Polyclonal (C-Terminus) (DY488) Antibody
Mouse, Rat
ICC, IF, IHC, WB
DY488 Conjugated
0.1 ml/$416
TRPM2 Rabbit anti-Human Polyclonal (aa431-480) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TRPM2 Rabbit anti-Human Polyclonal (aa431-480) (HRP) Antibody
Mouse, Guinea pig, Rat, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
TRPM2 Rabbit anti-Human Polyclonal (aa431-480) (Biotin) Antibody
Mouse, Guinea pig, Rat, Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
TRPM2 Rabbit anti-Human Polyclonal (aa431-480) (FITC) Antibody
Mouse, Guinea pig, Rat, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
TRPM2 Rabbit anti-Human Polyclonal (aa1204-1503) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
TRPM2 Rabbit anti-Human Polyclonal (aa60-119) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
TRPM2 Rabbit anti-Human Polyclonal Antibody
Human
IF, IP, WB
Unconjugated
100 µg/$865
TRPM2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
50 µg/$508
TRPM2 Rabbit anti-Human Polyclonal (aa181-423) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
TRPM2 Rabbit anti-Human Polyclonal (aa1200-1250) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$485
TRPM2 Rabbit anti-Mouse Polyclonal (Internal) Antibody
Mouse, Rat
WB
Unconjugated
0.1 ml/$386
TRPM2 Rabbit anti-Mouse Polyclonal (Internal) (Biotin) Antibody
Mouse, Rat
WB
Biotin Conjugated
0.1 ml/$416
TRPM2 Rabbit anti-Mouse Polyclonal (Internal) (DY488) Antibody
Mouse, Rat
WB
DY488 Conjugated
0.1 ml/$416
TRPM2 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
TRPM2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TRPM2 Rabbit anti-Human Polyclonal (aa1204-1503) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
TRPM2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
TRPM2 Rabbit anti-Human Polyclonal (aa650-700) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$520
TRPM2 Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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