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TRPM1 is a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants.
Gene Name: | transient receptor potential cation channel, subfamily M, member 1 |
Family/Subfamily: | Ion Channel , Calcium channel - TRP |
Synonyms: | TRPM1, CSNB1C, LTRPC1, Melastatin 1, Melastatin-1, MLSN1, MLSN |
Target Sequences: | NM_002420 NP_002411.3 Q7Z4N2 |
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