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Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
Gene Name: | transient receptor potential cation channel, subfamily C, member 6 |
Family/Subfamily: | Ion Channel , Calcium channel - TRP |
Synonyms: | TRPC6, Transient receptor protein 6, Trrp6, TRP-6, TRP6, FSGS2 |
Target Sequences: | NM_004621 NP_004612.2 Q9Y210 |
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