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TRPA1

transient receptor potential cation channel, subfamily A, member 1

Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.

Gene Name: transient receptor potential cation channel, subfamily A, member 1
Family/Subfamily: Ion Channel , Calcium channel - TRP
Synonyms: TRPA1, ANKTM1, TRPA-1
Target Sequences: NM_007332 CAA71610.1 O75762

Publications (8)

1
TRPA1 in mast cell activation-induced long-lasting mechanical hypersensitivity of vagal afferent C-fibers in guinea pig esophagus. Yu S, Gao G, Peterson BZ, Ouyang A. American journal of physiology. Gastrointestinal and liver physiology. 2009 297:G34-42. [PubMed:19423751]
2
Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice. Cattaruzza F, Spreadbury I, Miranda-Morales M, Grady EF, Vanner S, Bunnett NW. American journal of physiology. Gastrointestinal and liver physiology. 2010 298:G81-91. (ICC, IHC; Mouse) [PubMed:19875705] [PMC:PMC2806099]
3
Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal. Peyrot des Gachons C, Uchida K, Bryant B, Shima A, Sperry JB, Dankulich-Nagrudny L, Tominaga M, Smith AB, Beauchamp GK, Breslin PA. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:999-1009. (IHC-Fr; Human) [Full Text Article] [PubMed:21248124] [PMC:PMC3073417] Related Antibodies: LS-A9097.
4
Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine. Poole DP, Pelayo JC, Cattaruzza F, Kuo YM, Gai G, Chiu JV, Bron R, Furness JB, Grady EF, Bunnett NW. Gastroenterology. 2011 141:565-75, 575.e1-4. (ICC, IHC; Mouse) [PubMed:21689654]
5
Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells. Mukhopadhyay I, Gomes P, Aranake S, Shetty M, Karnik P, Damle M, Kuruganti S, Thorat S, Khairatkar-Joshi N. Journal of receptor and signal transduction research. 2011 31:350-8. (WB; Human) [PubMed:21848366]
6
Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice. Okubo K, Matsumura M, Kawaishi Y, Aoki Y, Matsunami M, Okawa Y, Sekiguchi F, Kawabata A. British journal of pharmacology. 2012 166:1738-43. [PubMed:22300342] [PMC:PMC3419915]
7
Calmodulin Supports TRPA1 Channel Association with Opioid Receptors and Glutamate NMDA Receptors in the Nervous Tissue. Elsa Cortés-Montero, María Rodríguez-Muñoz, María Del Carmen Ruiz-Cantero, Enrique José Cobos, Pilar Sánchez-Blázquez, Javier Garzón-Niño. International journal of molecular sciences. 2020 December;22: [Full Text Article] [PubMed:33379368] [PMC:PMC7795679] Related Antibodies: LS-C747641.
8
The role of the transient receptor potential (TRP) superfamily of cation-selective channels in the management of the overactive bladder. Andersson KE, Gratzke C, Hedlund P. The Journal of urology. 2011 Oct;106:1114-27. [Full Text Article] [PubMed:21156013] Related Antibodies: LS-A9097.
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Antibodies (34)
Primary (34)
TRPA1 (34)
Human (31)
Mouse (14)
Rat (10)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (2)
Horse (3)
Monkey (3)
Pig (3)
Zebrafish (1)
IHC (16)
IHC-Fr (6)
IHC-P (8)
WB (29)
ELISA (3)
ICC (4)
IF (4)
Peptide-ELISA (1)
rabbit (33)
sheep (1)
Product Group
Alzheimer's Disease (33)
IHCPlus (3)
PathPlus Neuro (1)
IgG (16)
polyclonal pc (34)
APC (1)
APC Conjugated (1)
Biotin Conjugated (3)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (20)
aa63-370 (8)
N-Terminus (7)
aa539-588 (4)
Internal (2)
aa1050-1120 (2)
4th Cytoplasmic Domain (1)
aa1-100 (1)
No (32)
Yes (2)
TRPA1 Antibody - Anti-TRPA1 antibody IHC of human ganglion cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
TRPA1 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IF, IHC, IHC-Fr, IHC-P
Unconjugated
50 µg/$460
TRPA1 Antibody - Anti-TRPA1 antibody IHC of human spinal cord, dorsal root ganglion. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
TRPA1 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
TRPA1 Antibody - TRPA1 antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human skeletal muscle, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
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TRPA1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$485
TRPA1 Antibody - TRPA1 antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human brain, cerebellum, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPA1 Rabbit anti-Human Polyclonal (aa1-100) Antibody
Mouse, Guinea pig, Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$460
TRPA1 Antibody - TRPA1 antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human brain, cerebellum, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPA1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Guinea pig, Human
ICC, IHC, IHC-Fr, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
TRPA1 Antibody - TRPA1 antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human brain, cerebellum, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPA1 Rabbit anti-Human Polyclonal (N-Terminus) (DY650) Antibody
Human
ICC, IHC, IHC-Fr, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
TRPA1 Antibody - TRPA1 antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human brain, cerebellum, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPA1 Rabbit anti-Human Polyclonal (N-Terminus) (DY488) Antibody
Human
ICC, IHC, IHC-Fr, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
TRPA1 Antibody - TRPA1 antibody (5 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human brain, cerebellum, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPA1 Rabbit anti-Human Polyclonal (N-Terminus) (DY550) Antibody
Human
ICC, IHC, IHC-Fr, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
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TRPA1 Rabbit anti-Rat Polyclonal (aa1050-1120) Antibody
Mouse, Rat
IHC, WB
Unconjugated
500 µg/$393
TRPA1 Antibody - Western blot analysis of extracts of various cell lines, using TRPA1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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TRPA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$389
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TRPA1 Sheep anti-Rat Polyclonal (aa1050-1120) Antibody
Mouse, Rat
IHC, WB
Unconjugated
500 µg/$393
TRPA1 Antibody - TRPA1 antibody Western blot of Fetal Stomach lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TRPA1 Rabbit anti-Human Polyclonal (aa539-588) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$424
TRPA1 Antibody - Immunohistochemistry of paraffin-embedded rat brain tissue.
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TRPA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
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TRPA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
TRPA1 Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using TRPA1 Polyclonal Antibody at dilution of 1:60.
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TRPA1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TRPA1 Antibody - Western blot of TRPA1 antibody.
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TRPA1 Rabbit anti-Human Polyclonal (aa63-370) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
TRPA1 Antibody - Western blot of TRPA1 antibody.
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TRPA1 Rabbit anti-Human Polyclonal (aa63-370) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
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TRPA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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TRPA1 Rabbit anti-Human Polyclonal (4th Cytoplasmic Domain) Antibody
Human
IHC, WB
Unconjugated
500 µg/$393
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TRPA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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TRPA1 Rabbit anti-Zebrafish Polyclonal (N-Terminus) Antibody
Zebrafish
IHC, WB
Unconjugated
500 µg/$393
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TRPA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
TRPA1 Antibody - Immunofluorescence analysis of Mouse intestine using TRPA1 Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
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TRPA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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TRPA1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
WB
Unconjugated
25 µl/$498; 100 µl/$763
TRPA1 Antibody
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TRPA1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
Viewing 1-25 of 34 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).