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Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Gene Name: | trimethylguanosine synthase 1 |
Synonyms: | TGS1, CLL-associated antigen KW-2, HCA137, PIMT, PIPMT, SEREX-defined, Trimethylguanosine synthase 1, NCOA6IP, PRIP-interacting protein PIPMT, Trimethylguanosine synthase |
Target Sequences: | NM_024831 NP_079107.6 Q96RS0 |
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