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TRIM3 is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.
Gene Name: | tripartite motif containing 3 |
Family/Subfamily: | Tripartite Motif |
Synonyms: | TRIM3, BERP, Brain expressed ring finger, Tripartite motif containing 3, Tripartite motif protein TRIM3, RING finger protein 97, RNF22, RNF97, HAC1, RING finger protein 22, Tripartite motif-containing 3 |
Target Sequences: | NM_006458 NP_006449.2 O75382 |
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