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Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Gene Name: | triadin |
Synonyms: | TRDN, TDN, Triadin, TRISK, TRISK51 |
Target Sequences: | NM_006073 NP_006064.2 Q13061 |
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