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TRDMT1 / DNMT2 is a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa.
Gene Name: | tRNA aspartic acid methyltransferase 1 |
Family/Subfamily: | C5-methyltransferase |
Synonyms: | TRDMT1, DMNT2, DNA MTase homolog HsaIIP, DNMT2, M.HsaIIP, MHSAIIP, RNMT1, DNA methyltransferase-2, PUMET |
Target Sequences: | NM_004412 NP_004403.1 O14717 |
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