TRB3 / TRIB3

tribbles pseudokinase 3

Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

TRB3 / TRIB3 (6)

Publications

No (6)

Tag

GST (2)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

Baculovirus (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

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Human TRB3 / TRIB3 Protein (Recombinant His) - LS-G3136

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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Human TRB3 / TRIB3 Protein (Recombinant GST) (Full Length) - LS-G34800

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

65.12 kDa

Price:

10 µg/$479; 25 µg/$670

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Human TRB3 / TRIB3 Protein (Recombinant GST, N-terminus) (aa56-145) - LS-G63001

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TRB3 / TRIB3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91487

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.4 kDa

Price:

20 µg/$150

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TRB3 / TRIB3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101732

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.4 kDa

Price:

100 µg/$494

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Human TRB3 / TRIB3 Protein (Recombinant GST) (Met1-Gly358) - LS-G97981

Source:

Baculovirus

Tag:

GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

65.8 kDa

Price:

50 µg/$561

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