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TRAIL-R3 / DCR1

tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

Gene Name: tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Family/Subfamily: TNF Receptor , not assigned-TNF Receptor
Synonyms: TNFRSF10C, CD263 antigen, CD263, Cytotoxic TRAIL receptor-3, Decoy receptor 1, DCR1, DCR1-TNFR, LIT, Lymphocyte inhibitor of TRAIL, TRAIL-R3, TRAILR3, TRAIL receptor 3, TRID
Target Sequences: NM_003841 NP_003832.2 O14798

Publications (1)

1
Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL. Souza PS, Madigan JP, Gillet JP, Kapoor K, Ambudkar SV, Maia RC, Gottesman MM, Fung KL. Experimental cell research. 2015 August;336:318-28. (Human) [Full Text Article] [PubMed:26101157] [PMC:PMC4522412]

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Proteins (9)
Recombinant (9)
TRAIL-R3 / DCR1 (9)
No (9)
6His, C-terminus (3)
Fc/6His,C-terminus (1)
Fc-6His, C-terminus (2)
GST (1)
His (1)
His-GST (1)
Human (9)
E. coli (2)
Human Cells (2)
Mammalian Cells (4)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (6)
Biologically active (2)
TRAIL-R3 / DCR1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.78kD
10 µg/$240; 50 µg/$299; 500 µg/$929; 1 mg/$1,245
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Human Cells
Fc-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.7kD
10 µg/$248; 50 µg/$321; 500 µg/$785; 1 mg/$1,021
TRAIL-R3 / DCR1 Protein - 12.5% SDS-PAGE of human TNFRSF10C stained with Coomassie Blue
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Wheat Germ Extract
GST
53.8 kDa
2 µg/$439
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Mammalian Cells
Fc/6His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.7 kDa
10 µg/$248; 50 µg/$317
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Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
21.78 kDa
50 µg/$327; 10 µg/$250; 1 mg/$1,518; 500 µg/$1,170
Select
Mammalian Cells
Fc-6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
48.7 kDa
50 µg/$356; 10 µg/$259; 1 mg/$1,261; 500 µg/$1,025
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
21.8 kDa
10 µg/$240; 50 µg/$299
TRAIL-R3 / DCR1 Protein - Recombinant  Tumor Necrosis Factor Receptor Superfamily, Member 10C By SDS-PAGE
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E. coli
His-GST
52.4 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).