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Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.
Gene Name: | TPX2, microtubule-associated |
Synonyms: | TPX2, C20orf2, DIL-2, DIL2, HCA519, GD:C20orf1, p100, Protein fls353, Targeting protein for Xklp2, C20orf1, FLS353, HCTP4, REPP86 |
Target Sequences: | NM_012112 NP_036244.2 Q9ULW0 |
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