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TPX2
TPX2, microtubule-associated
Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.
| Gene Name: | TPX2, microtubule-associated |
| Synonyms: | TPX2, C20orf2, DIL-2, DIL2, HCA519, GD:C20orf1, p100, Protein fls353, Targeting protein for Xklp2, C20orf1, FLS353, HCTP4, REPP86 |
| Target Sequences: | NM_012112 NP_036244.2 Q9ULW0 |
Publications (6)
1
Tumor cell dependence on Ran-GTP-directed mitosis. Xia F, Lee CW, Altieri DC. Cancer research. 2008 68:1826-33.
[PubMed:18339863]
2
A survivin-ran complex regulates spindle formation in tumor cells. Xia F, Canovas PM, Guadagno TM, Altieri DC. Molecular and cellular biology. 2008 28:5299-311.
[PubMed:18591255]
[PMC:PMC2519733]
3
Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. Bird AW, Hyman AA. The Journal of cell biology. 2008 182:289-300.
[PubMed:18663142]
[PMC:PMC2483532]
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(55)
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TPX2
(55)
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(35)
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1696CT464.66.9
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18D5
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19AT738.292
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19AT953.286.93
(1)
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3164C6a
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(4)
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(4)
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(6)
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(4)
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(29)
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(7)
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(1)
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(1)
Publications
No
(54)
Yes
(1)
TPX2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Pig, Mammal, Human
IHC, IHC-P
Unconjugated
0.1 ml/$460
TPX2 Mouse anti-Human Monoclonal (18D5) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
TPX2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
Flo, IF, IP, WB
Unconjugated
100 µl/$649
TPX2 Mouse anti-Human Monoclonal (3164C6a) Antibody
Human
DB, Flo, ICC, IP, WB
Unconjugated
100 µg/$486
TPX2 Rabbit anti-Human Polyclonal (aa301-350) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
TPX2 Mouse anti-Human Monoclonal (19AT738.292) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
TPX2 Rabbit anti-Human Polyclonal (aa281-330) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
TPX2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TPX2 Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IP, WB
Unconjugated
100 µg/$786
TPX2 Rabbit anti-Human Polyclonal (aa150-200) Antibody
Human
ICC, IF, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
TPX2 Mouse anti-Human Monoclonal (TPX2-01) Antibody
Mouse, Rat, Human
ELISA, ICC, IHC-P, IP, WB
Unconjugated
0.1 mg/$330
TPX2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IP, WB
Unconjugated
100 µg/$341
TPX2 Mouse anti-Human Monoclonal (aa1-220) (1D4B) Antibody
Human
IF, IHC, WB
Unconjugated
100 µg/$587
TPX2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
TPX2 Rabbit anti-Human Polyclonal (aa350-382) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
TPX2 Rabbit anti-Human Polyclonal (aa350-382) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
TPX2 Rabbit anti-Human Polyclonal (aa350-382) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
TPX2 Rabbit anti-Human Polyclonal (aa350-382) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
TPX2 Rabbit anti-Human Polyclonal (aa350-382) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
TPX2 Rabbit anti-Human Polyclonal (aa350-382) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
TPX2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
TPX2 Rabbit anti-Human Polyclonal (270-350 aa, Internal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TPX2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
TPX2 Rabbit anti-Human Polyclonal (aa350-382) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
TPX2 Mouse anti-Human Monoclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
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