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Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).
Gene Name: | toll interacting protein |
Synonyms: | TOLLIP, Adapter protein, IL-1RAcPIP, Toll interacting protein, Toll-interacting protein |
Target Sequences: | NM_019009 NP_061882.2 Q9H0E2 |
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