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TNS1 / Tensin-1 localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene Name: | tensin 1 |
Synonyms: | TNS1, MST091, MST127, MSTP127, MST122, Tensin 1, MSTP091, Tensin, Tensin-1, MSTP122, MXRA6, TNS |
Target Sequences: | NM_022648 NP_072174.3 Q9HBL0 |
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