Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Gene Name: | transportin 2 |
Synonyms: | TNPO2, Transportin 2, TRN2, Transportin-2, Importin 3, IPO3, Karyopherin beta-2b, KPNB2B |
Target Sequences: | NM_013433 NP_038461.2 O14787 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.