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TNNI3 / Cardiac Troponin I

troponin I type 3 (cardiac)

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Gene Name: troponin I type 3 (cardiac)
Synonyms: TNNI3, CTnI, CMD1FF, CMD2A, RCM1, Troponin I, cardiac, Troponin I, cardiac muscle, Troponin I type 3 (cardiac), Cardiac troponin I, CMH7
Target Sequences: NM_000363 NP_000354.4 P19429

Publications (5)

1
Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance. Kirthana Ganeshan, Joni Nikkanen, Kevin Man, Yew Ann Leong, Yoshitaka Sogawa, J Alan Maschek, Tyler Van Ry, D Nyasha Chagwedera, James E Cox, Ajay Chawla. Cell. 2019 April;177:399-413.e12. [Full Text Article] [PubMed:30853215] [PMC:PMC6456449]
2
MR-guided pulsed focused ultrasound improves mesenchymal stromal cell homing to the myocardium. Kee W Jang, Tsang-Wei Tu, Robert B Rosenblatt, Scott R Burks, Joseph A Frank. Journal of cellular and molecular medicine. 2020 October; [Full Text Article] [PubMed:33067927] [PMC:PMC7701528]
3
Assessment of inflammatory markers and mitochondrial factors in a rat model of sepsis-induced myocardial dysfunction. Xiao-Mei Zeng, De-Hong Liu, Yong Han, Zhi-Qiang Huang, Ji-Wen Zhang, Qun Huang. American journal of translational research. 2020 April;12:901-911. [PubMed:32269722] [PMC:PMC7137057]
4
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy10<sup> Department of Molecular Cardiology, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht, Utrecht, The Netherlands12<sup> Department of Cell and Molecular Biology (CMB), Karolinska Institute, Stockholm, Sweden14<sup> Department of Cardiology University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. p.van.der.meer. Niels Grote Beverborg #, Daniela Später # , Ralph Knöll # , Alejandro Hidalgo , Steve T Yeh, Zaher Elbeck, Herman H W Silljé, Tim R Eijgenraam, Humam Siga, Magdalena Zurek, Malin Palmér , Susanne Pehrsson, Tamsin Albery, Nils Bomer, Martijn F Hoes, Cornelis J Boogerd, Michael Frisk, Eva van Rooij, Sagar Damle, William E Louch, Qing-Dong Wang, Regina Fritsche-Danielson, Kenneth R Chien , Kenny M Hansson, Adam E Mullick, Rudolf A de Boer, Peter van der Meer. Nature communications. 2021 Aug;12:5180. [Full Text Article] [PubMed:34462437] [PMC:PMC8405807]
5
The Selective NLRP3-inflammasome inhibitor MCC950 Mitigates Post-resuscitation Myocardial Dysfunction and Improves Survival in a Rat Model of Cardiac Arrest and Resuscitation. Guanghui Zheng, Fenglian He, Jing Xu, Juntao Hu, Weiwei Ge, Xianfei Ji, Changsheng Wang, Jennifer L Bradley, Mary Ann Peberdy, Joseph P Ornato, Longyuan Jiang, Stefano Toldo, Tong Wang , Wanchun Tang. Cardiovascular drugs and therapy. 2022 January; [Full Text Article] [PubMed:34973094]
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Proteins (18)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (3)
Recombinant (13)
TNNI3 / Cardiac Troponin I (18)
No (18)
10His, N-terminus + Myc, C-terminus (1)
6His, N-terminus (4)
6His-SUMO, N-terminus (1)
DDK,C-terminus (1)
GST (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (2)
His-T7 (2)
Myc-DDK (Flag) (3)
Bovine (1)
Dog (1)
Human (11)
Mouse (2)
Pig (1)
Rat (1)
293T Cells (1)
E. coli (10)
HEK 293 Cells (4)
Sf9 Cells (1)
Wheat Germ Extract (2)
Purified (5)
TNNI3 / Cardiac Troponin I Protein
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Mouse TNNI3 / Cardiac Troponin I Protein (Recombinant His, N-Terminal) (Met1-Gly211) - LS-G12242
E. coli
His, N-Terminal
25.8 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
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Human TNNI3 / Cardiac Troponin I Protein (Recombinant 6His, N-terminus) - LS-G145624
E. coli
6His, N-terminus
26 kDa
1 mg/$2,029; 10 µg/$253; 50 µg/$308
TNNI3 / Cardiac Troponin I Protein - Recombinant Troponin I Type 3, Cardiac By SDS-PAGE
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Rat TNNI3 / Cardiac Troponin I Protein (Recombinant His, N-Terminal) (aa1-211) - LS-G12246
E. coli
His, N-Terminal
25.7 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
TNNI3 / Cardiac Troponin I Protein - Recombinant Troponin I Type 3, Cardiac By SDS-PAGE
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Human TNNI3 / Cardiac Troponin I Protein (Recombinant His) (aa1-203) - LS-G12236
E. coli
His
24.6 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
TNNI3 / Cardiac Troponin I Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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Human TNNI3 / Cardiac Troponin I Protein (Recombinant 6His, N-terminus) (Ala2-Ser210) - LS-G26583
E. coli
6His, N-terminus
26.1 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 200 µg/$484
TNNI3 / Cardiac Troponin I Protein - Recombinant Troponin I Type 3, Cardiac By SDS-PAGE
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Dog TNNI3 / Cardiac Troponin I Protein (Recombinant His-T7) (aa1-211) - LS-G12238
E. coli
His-T7
27.7 kDa
10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359
TNNI3 / Cardiac Troponin I Protein - Purified recombinant protein TNNI3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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Human TNNI3 / Cardiac Troponin I Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67203
HEK 293 Cells
Myc-DDK (Flag)
23.8 kDa
20 µg/$1,107
TNNI3 / Cardiac Troponin I Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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Human TNNI3 / Cardiac Troponin I Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79330
293T Cells
Myc-DDK (Flag)
23.8 kDa
20 µg/$215
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Human TNNI3 / Cardiac Troponin I Protein - LS-G133993
E. coli
None
24 kDa
10 µg/$326; 50 µg/$406; 1000 µg/$2,576
TNNI3 / Cardiac Troponin I Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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TNNI3 / Cardiac Troponin I Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123236
HEK 293 Cells
Myc-DDK (Flag)
23.8 kDa
100 µg/$710
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Bovine TNNI3 / Cardiac Troponin I Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (Full Length) - LS-G137457
E. coli
10His, N-terminus + Myc, C-terminus
39.0 kDa
1 mg/$1,679; 100 µg/$598; 20 µg/$405
TNNI3 / Cardiac Troponin I Protein
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Human TNNI3 / Cardiac Troponin I Protein (Recombinant DDK,C-terminus) - LS-G142432
Sf9 Cells
DDK,C-terminus
23.8 kDa
20 µg/$677
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Human TNNI3 / Cardiac Troponin I Protein (Over-Expression Lysate 6His, N-terminus) (Ala2-Ser210) - LS-G26797
HEK 293 Cells
6His, N-terminus
26 kDa
100 µg/$298
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Human TNNI3 / Cardiac Troponin I Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Ala2-Ser210) - LS-G26933
HEK 293 Cells
6His, N-terminus
26 kDa
200 µl/$283
TNNI3 / Cardiac Troponin I Protein - Recombinant Troponin I Type 3, Cardiac By SDS-PAGE
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Pig TNNI3 / Cardiac Troponin I Protein (Recombinant His-T7) (aa2-211) - LS-G24031
E. coli
His-T7
27.6 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
TNNI3 / Cardiac Troponin I Protein - 12.5% SDS-PAGE of human TNNI3 stained with Coomassie Blue
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Human TNNI3 / Cardiac Troponin I Protein (Recombinant GST) (Full Length) - LS-G30743
Wheat Germ Extract
GST
48.73 kDa
2 µg/$439
TNNI3 / Cardiac Troponin I Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Mouse TNNI3 / Cardiac Troponin I Protein (Recombinant 6His-SUMO, N-terminus) (aa2-211) - LS-G56659
E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
TNNI3 / Cardiac Troponin I Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Human TNNI3 / Cardiac Troponin I Protein (Recombinant GST, N-terminus) (aa102-210) - LS-G60393
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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