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TNNI1

troponin I type 1 (skeletal, slow)

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

Gene Name: troponin I type 1 (skeletal, slow)
Synonyms: TNNI1, Troponin I, skeletal, slow, SSTNI, TNN1
Target Sequences: NM_003281 NP_003272.3 P19237

Publications (2)

1
Large increases in plasma fast skeletal muscle troponin I after whole-body eccentric exercises. Large increases in plasma fast skeletal muscle troponin I after whole-body eccentric exercises. Journal of science and medicine in sport. 2020 August;23:776-781. [Full Text Article] [PubMed:32067915]
2
Elevation of fast but not slow troponin I in the circulation of patients with Becker and Duchenne muscular dystrophy. Benjamin L Barthel, Dan Cox, Marissa Barbieri, Michael Ziemba, Volker Straub, Eric P Hoffman, Alan J Russell. Muscle & nerve. 2021 Jul;;64:43-49. [Full Text Article] [PubMed:33683712] [PMC:PMC8362156]

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Products
Antibodies (60)
Primary (60)
TNNI1 (60)
Human (28)
Mouse (32)
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Chicken (3)
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IgG2b,k (1)
monoclonal mc (19)
polyclonal pc (41)
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aa1-187 (32)
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aa111-160 (4)
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No (60)
TNNI1 Antibody - Anti-TNNI1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TNNI1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TNNI1 Antibody - Anti-TNNI1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TNNI1 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Rabbit, Mouse, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
TNNI1 Antibody - Anti-TNNI1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TNNI1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Rabbit, Mouse, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
TNNI1 Antibody - Anti-TNNI1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TNNI1 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Rabbit, Mouse, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
TNNI1 Antibody
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TNNI1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$332
TNNI1 Antibody - Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TNNI1 Rabbit anti-Human Polyclonal (aa111-160) Antibody
Human
WB
Unconjugated
100 µl/$397
TNNI1 Antibody
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TNNI1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
100 µl/$332
TNNI1 Antibody - IHC of paraffin-embedded Human adult heart tissue using anti-TNNI1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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TNNI1 Mouse anti-Human Monoclonal (OTI8H8) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
TNNI1 Antibody - Immunohistochemical staining of paraffin-embedded Human adult heart tissue using anti-TNNI1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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TNNI1 Mouse anti-Human Monoclonal (Carrier-free) (OTI8H8) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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TNNI1 Mouse anti-Mouse Monoclonal Antibody
Mouse
ICC, IP, WB
Unconjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$597
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TNNI1 Mouse anti-Mouse Monoclonal (HRP) Antibody
Mouse
ICC, IP, WB
HRP Conjugated
100 µl/$351; 200 µl/$411; 500 µl/$618; 1 ml/$774
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TNNI1 Mouse anti-Mouse Monoclonal (Biotin) Antibody
Mouse
ICC, IP, WB
Biotin Conjugated
100 µl/$329; 200 µl/$381; 500 µl/$550; 1 ml/$654
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TNNI1 Mouse anti-Mouse Monoclonal (FITC) Antibody
Mouse
ICC, IP, WB
FITC Conjugated
100 µl/$362; 200 µl/$427; 500 µl/$666; 1 ml/$826
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TNNI1 Mouse anti-Mouse Monoclonal (Cy3) Antibody
Mouse
ICC, IP, WB
Cy3 Conjugated
100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084
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TNNI1 Mouse anti-Mouse Monoclonal (PE) Antibody
Mouse
ICC, IP, WB
PE Conjugated
100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084
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TNNI1 Mouse anti-Mouse Monoclonal (APC, Cy7) Antibody
Mouse
ICC, IP, WB
APC, Cy7 Conjugated
100 µl/$535; 200 µl/$714; 500 µl/$1,236; 1 ml/$1,545
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TNNI1 Mouse anti-Mouse Monoclonal (APC) Antibody
Mouse
ICC, IP, WB
APC Conjugated
100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084
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TNNI1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
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TNNI1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
TNNI1 Antibody - Immunofluorescent analysis of HepG2 cells using TNNI1 Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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TNNI1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
TNNI1 Antibody - TNNI1 antibody (0.03 ug/ml) staining of Human Skeletal Muscle lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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TNNI1 Goat anti-Human Polyclonal (aa2-15) Antibody
Goat, Pig, Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
TNNI1 Antibody - Detection limit for recombinant GST tagged TNNI1 is approximately 1 ng/ml as a capture antibody.
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TNNI1 Mouse anti-Human Monoclonal (4G6) Antibody
Human
ELISA
Unconjugated
100 µg/$423
TNNI1 Antibody - Western blot of recombinant TNNI1.
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TNNI1 Rabbit anti-Mouse Polyclonal (aa1-187) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571
TNNI1 Antibody - Western blot of recombinant TNNI1.
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TNNI1 Rabbit anti-Mouse Polyclonal (aa1-187) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777
TNNI1 Antibody - Western blot of recombinant TNNI1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TNNI1 Rabbit anti-Human Polyclonal (aa1-187) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).